After taking down a terrorist, the FBI and their Fugitive Task Force partners turn their attention to the terrorist’s wife who escaped with one million dollars and is determined to follow through with her husband’s deadly plan. Also, LaCroix’s daughter, Tali, is taken away by ICE, but as Jess tracks her down, he realizes her detainment may be more than just random coincidence.

The crossover starts on FBI S02E18 American Dreams (I).

The clock ticks as the FBI and FBI: Most Wanted teams join forces to hunt down the fugitive terrorists as they get closer to carrying out a plot to destroy a major New York City landmark and cause devastating civilian casualties.

The crossover starts on FBI: International S02E16 Imminent Threat (I) and FBI S05E17 Imminent Threat (II).