Detective Ruditsky relates the story of Nick Joseph, a small-time hood from Manhattan's Lower East Side, who rises from petty theft to become an ace contract killer for the syndicate's notorious Murder, Inc.

An immigrant woman tries to get Ruditsky to set her son on the straight and narrow. It seems as though he's been hanging around with a gang of hoodlums. Ruditsky gives it his best effort but it could be a tough sell.

Dutch Schultz wants to bump off special prosecutor Thomas Dewey who has been after him. The syndicate bigwigs deny him permission to make the hit but the Dutchman proceeds with his plans anyway.

The body of a murdered young woman is dragged from the Harlem River and the police ascertain that she was killed because she knew too much regarding the activities of a bootlegging gang. Ruditsky then becomes puzzled when the attorney of the chief suspect insists on going to trial as quickly as possible.

Ex-convict Maxey Gorman gets a Machiavellian character named A.J. to finance his entry into the bootlegging business. The two men become partners but when the dough starts pouring in Maxie looks for a way to rid himself of A. J.

Muddy Kasoff has been renting automobiles for gangsters to use but he has been secretly tippin the cops. When the hoods discover that Muddy has been informing they have him killed. Ruditsky investigates and discovers that a cigar band might be an important clue.

A judge is murdered right before a state crime commission is scheduled to take a look into his activities.

When the trail of a murdered garment factor owner leads back to the notorious Lepke Buchalter he sends the htman responsible, Big Greeny, to stay in Los Angeles under the auspices of the equally notorious Bugsy Siegal.

Mob boss Bobo Konig puts a bounty of $50,000 on psychotic gunman Billy Boy Creel who immediately goes underground. Ruditsky then tries to find Billy Boy before Konig's killers do.