Antonio heads undercover with a dangerous robbery crew after a narcotics officer goes missing.

Nach einer Reihe von Wohnungseinbrüchen sucht das Team nach dem roten Faden in der Sache.

Platt is sent to the hospital after a vicious attack outside her father's house. Mouch is questioned and past threats against her are revisited while the team investigates. A gruesome discovery inside the father's home ups the ante in the case.

Severide is brought into the District for questioning after his car is found to have caused a deadly crash. As the investigation gets underway, the team works to uncover a group of car-jackers who may be the key to Severide's innocence.

The crossover starts on Chicago Fire S05E09 Some Make It, Some Don't (I).

In der 100. Episode von Chicago P.D. hat es das Team mit einer Reihe von Bombenanschlägen zu tun, die gezielt Angestellte der Medien ins Visier nehmen. Ein Wettlauf gegen die Zeit beginnt und das Team zieht das Firehouse-51-Department zur Hilfe, um weitere Anschläge zu verhindern.

Das Crossover wird fortgesetzt bei Chicago Fire 6x13 "Versteckspiele (2)".

After zeroing in on the suspect responsible for the bioterrorism that’s gripping Chicago, the PD prepares to undertake their biggest manhunt yet. Upton is torn between helping track down the perp and providing emotional support to the scared young girl that needs her. Voight fears his team is being sent on a wild goose chase.

The crossover starts on Chicago Fire S08E04 Infection (I) and Chicago Med S05E04 Infection, Part II (II).

Intelligence searches for the dealer who caused multiple overdoses and is connected to Roman's missing sister. The case becomes a homicide investigation when they find the dealer's dead body.

The crossover starts on Chicago Fire S08E15 Off the Grid (I).