The TARDIS brings its crew to a quarantine facility for victims of an alien plague. When Amy is trapped, Rory must rescue her from the facility's doctors but learns something surprising about his wife.

The trio arrive at a hotel where the layout of the rooms keeps changing. It also contains rooms that hold the greatest fears of each visitor.

Kidnapped by his oldest foe, the Doctor is forced on an impossible mission - to a place even the Daleks are too terrified to enter... the Asylum. A planetary prison confining the most terrifying and insane of their kind, the Doctor and the Ponds must find an escape route. But with Amy and Rory’s relationship in meltdown, and an army of mad Daleks closing in, it is up to the Doctor to save their lives, as well as the Pond’s marriage.

The Doctor’s heart-breaking farewell to Amy and Rory – a race against time through the streets of Manhattan, as New York’s statues come to life around them… With Rory’s life in danger, the Doctor and Amy must locate him before it’s too late! Luckily, an old friend helps them and guides the way.

The Doctors embark on their greatest adventure in this 50th anniversary special. In 2013, something terrible is awakening in London's National Gallery; in 1562, a murderous plot is afoot in Elizabethan England; and somewhere in space an ancient battle reaches its devastating conclusion. All of reality is at stake as the Doctor's own dangerous past comes back to haunt him.