An ingenious art theft takes place at Comus Towers Art Museum, and a guard is murdered in the process. Chief Ironside takes the case, but another death is to follow; this time the proprietor of the museum, who is an old friend of the Chief's.

The star witness to a major case, Ed is shot and seriously injured by a mystery assailant. Threatened with paralysis he conducts his own struggle from within his hospital bed, whilst the Chief tries to find out who is still trying to kill his prize pupil. Meanwhile Ed's best chance of recovery is an untested experimental operation performed by a surgeon whose integrity is very likely about to be put to the test.

The crossover continues on The Bold Ones: The New Doctors S04E01 Five Days in the Death of Sgt. Brown (II).