It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.

Dana takes a leave from the clinic to help her mother through a double mastectomy. Lu's impromptu safe-sex speech at a prep school's career day puts her in the middle of a legal dispute over a date rape. Peter's ""alternative"" approach to pain management for a patient with Hodgkin's disease gets them both arrested. And Dana and Lu must each decide how much they want to know when they are both tested for the mutated BRCA1 and BRCA2 genes that would reveal a predisposition to breast cancer.