Billie Jo receives a $500 insurance endowment, which her late father set aside for his first-born to become a doctor. But Billie Jo wants to go to Hollywood to become an actress. Kate thinks that Hooterville's long time doctor, Dr. Depew, can talk Billie Jo into it. But Kate's thinks that Dr. Depew's handsome new assistant, Dr. Clayton Harris, would be able to convince Billie Jo even more. So using Uncle Joe as a patient with non-existing symptoms, Kate hopes to have Dr. Harris make a thorough examination with Billie Jo as his assistant, exposing her to the wonders of modern medicine. But, Billie Jo faints at the first sight of blood.

Betty Jo has her first crush on a boy named Orville Miggs. But the object of her affections is more interested in tinkering with cars than he is in romance. As such, all Orville sees in Betty Jo is a mechanic's expert assistant. Kate doesn't want to see Betty Jo get hurt. Kate thinks he will see her in a different and more romantic light if she wears a dress and becomes a bit more feminine. But nothing they try makes Orville really notice Betty Jo, and ultimately give her her much wanted first kiss. If the family is able to accomplish their task, will Betty Jo ultimately think it was worth it?

Beatlemania has hit Hooterville by storm. Uncle Joe recruits Billy, Bobbie, and Betty Joe along with their friend Sally Ragsdale to form their own band called the Ladybugs. Colonel Partridge, a booking agent, comes to the Shady Rest to see the girls in action. Partridge likes what he hears and wants to book the girls. Sally's father, Sheriff Ragsdale, comes by and says he wants his daughter to finish school and not tour the country. Uncle Joe thinks he has a way to save the group and dresses up as a Ladybug.

Norman Curtis, President of the C&FW Railroad, is currently on vacation in Europe. He left instructions not to do anything to the Cannonball while he's gone. However, Homer Bedloe has a scheme to shut down the Cannonball for good. He hopes to do it without disobeying Curtis' orders. The plan entails Bedloe being appointed Superintendent of the Cannonball. He would then enforce an efficiency program with an impossible to meet new schedule. He expects Charley and Floyd will eventually just give up. Kate and the gang go to the stockholders meeting where she believes they've got a secret weapon to ruin Bedloe's plans.