A couple in Louisville, Kentucky who both suffer from hoarding risk losing their children if they don't comply with numerous citations given to them by the city. A woman's food hoarding in Milwaukee, Wisconsin is so bad that she places herself at risk for food poisoning.

A Kansas woman's compulsive shopping habits have taken over the entire house. Her children were removed by authorities as a result of the living conditions. A Beverly, Massachusetts man's hoard of both home renovation supplies and outdated materials is so bad that his common-law wife broke her arm tripping over a pile of his things. After seeming unfazed over the accident, he is given an ultimatum to clean up or move out.

A hoarding woman may lose her daughter; a groom never moved in to his wife's cluttered house.

Roy is facing $20 million in fines from the county for hoarding hundreds of vehicles on his property. A successful inventor, Roy is unable to part with what he considers materials for new inventions. If he doesn't remove all the vehicles and the hoard within them, the only way he will be able to pay this enormous fine is by selling off his land. Loretta and her husband were robbed at gunpoint and later had their home looted by thieves. They started over in a different neighborhood but the trauma and loss triggered Loretta's compulsion to hoard everything in their new home. With her second child due any day, Loretta must now clean up or face the involvement of CPS.

Verna is a hot-headed ex-cop, ex-drug trafficker, and ex-prison inmate who has cleverly evaded laws against hoarding by arguing that her hoard was her artistic expression. But now Verna, who has diabetes, is hospitalized, and the hospital refuses to let her return home unless it’s cleaned up. Joanne’s house has gone from immaculate showplace to garbage pit. Yet despite the filth, she’s been the daytime caretaker for her six-year-old grandson. Joanne’s sister-in-law is so upset about the situation that she’s threatening to call adult protective services if the house isn’t cleaned up immediately.