In this intro to the series, Dr. Jack Morrison treats a young girl with dysentary; Dr. Annie Cavanero searches for a missing patient -- who happens to be a large, permanent resident of a local mental institution; Dr. Ben Samuels tries to recall all of his conquests after being diagnosed with VD; Dr. Daniel Auschlander's liver cancer is revealed; a bombing victim is brought into the ER, as is the young man who set off the bomb; and Dr. Wayne Fiscus and Dr. Cathy Martin begin a relationship.

While coping with a fussy new administrator, Dr. Westphall investigates suspicious deaths in Ward Five; Martin shocks Fiscus by breaking off their affair; Cavanero has to deal with a very hostile nurse; and White goes to desperate lengths to raise the money to replace his on-call beeper.

Dr. Westphall risks his job by creating an isolation floor to stem the spread of the suspected Legionnaire's Disease (and the PR fiasco causes administrator Cummings to fall on his sword to save the hospital); Dr. Beale learns that Tweety got pregnant while in the hospital; Fiscus is assaulted in the E.R.; and Dr. Craig decides to sell his car.