Dr. Sloan's birthday is less than festive when he discovers the body of a prominent divorce lawyer in the Hospital pharmacy. When Steve arrives, the body is nowhere to be found. Mark and Jack work feverishly to find the body, find the culprit, and lead a tour of potential investors all at the same time.

Ashley York murders her wealthy father and cleverly manipulates it to appear as though he killed himself. Dr. Sloan picks away at holes in the story, which leads him directly to Ashley.

A burglar inadvertently becomes infected with a deadly virus. Dr. Sloan and Jesse are subsequently exposed to the virus after Jesse stumbles upon the thief's dead body. Both Mark and Jesse are confined to Mark's home while Steve and Amanda investigate the drug company that manufactured the virus, in the hopes of discovering an antidote before Jesse runs out of time.

Dr. Sloan investigates a photographer, the overly protective mother of Jesse's friend's fiancée, in the murder of a private investigator.

Mark's daughter returns after eight years, leaving an abusive husband who later turns up dead.

When a famous prostitute writes a tell-all book, an executive's job at Community General is in serious jeopardy.

Jesse's new part-time job as trainer of the pro basketball Mustangs turns deadly when he's accused of murdering a star player.

A madman charges into a Lamaze class with a bomb, claiming that a fertility doctor was cheating him. Everything is complicated further when said doctor turns up dead.

Ein vierjähriges Mädchen wird mit Erstickungsanfällen ins Krankenhaus eingeliefert. Während Dr. Sloan und Dr. Travis sich darum kümmern, das Mädchen in ein anderes Krankenhaus zu verlegen, stirbt es. Ihre Mutter verklagt daraufhin das Krankenhaus.

Amanda enlists Jesse's computer-nerd friends to find a killer, after she accidentally surfs across an on-line murder. Meanwhile, Jesse's girlfriend, Susan, comes down with a case of food poisoning after dining at Barbecue Bob's.

Assistenzarzt Mickey und seine Frau Jill passen in Dr. Mark Sloans Abwesenheit auf dessen Haus auf. Sie geraten so heftig in Streit, dass Jill Mickey tötet. Mark und Steve gegenüber behauptet sie jedoch, Einbrecher hätten Mickey auf dem Gewissen.