A romantic escapade goes horribly wrong when a young couple are involved in a motorbike accident, and the tragic events of the night leave the staff of St Aiden's struggling to heal more than just a broken heart. Dr. Ormerod grows suspicious when one of his patients is uneasy about returning home, but an investigation by Matron soon reveals the reasons for his reluctance. Meanwhile, Ken and Alun face trouble when a plague of rodents looks set to close down the hospital - but is local rogue Claude Greengrass really the best person to ask for advice?

Ormerod rushes to help following a boating accident, but realises he's been sent to the wrong location, and when he finally arrives at the disaster scene, his efforts to save a man's life prove futile. On returning to the hospital, he angrily chastises Lizzie for the misinformation - only to realise he was too hasty in blaming her. Can he make amends? Meanwhile, PC Ventress comes to the Royal with two men who had been fighting over a girl, and one promptly collapses due to a brain haemorrhage. Weatherill faces a testing time when she helps deliver a baby which is tragically stillborn and nurse Meryl reveals she suspects she may be pregnant.

Jill and Gordon's wedding day finally arrives, but a huge explosion at a nearby care home disrupts proceedings in spectacular fashion. As the Royal staff help pull the elderly residents out of the rubble, the horrifying truth behind the cause of the accident is discovered.

Mr. Harper prepares for the arrival of an important private patient, who proves useful when a badly injured teenager is brought in after an industrial accident after Dr. Goodwin puts his career on the line to fight for justice for the accident victim. Sister Brigid helps a terminally ill alcoholic called Rory, and Lizzie comes to terms with her husband's recent behaviour and looks ahead to the future.