Live from New York, it's... Andy Samberg!

Sketches include "A Message from Kevin Federline," "Veritas Ultrasound HD," "2007 National Douchebag Championships," "MacGruber" (three parts), "Jeremy and Sasha," "Fred Thompson '08," "America's First Colonists," "Rowlf & The Swedish Chef," and "Mad Joe Dixon."

Spoon performed "The Underdog" and "You Got Your Cherry Bomb."

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Cold Open: Coachella Music Festival

Sketches: Just Say No, Helen at the Party, Blue River Dog Food, Only Once Engagement, Undercover Sharpton, Every Sperm Must Go!

Pretaped: CNN Pregnancy Test, Monster Pals, A Very Smoky 420