Por todo o país, vampiros "saíram do caixão" depois da invenção de sangue sintético produzido em massa. Na Luisiana, Sookie Stackhouse, uma empregada de mesa com capacidades telepáticas, cai sob o feitiço de um vampiro sexy de 173 anos chamado Bill Compton — cujos pensamentos ela não consegue ler. Entretanto, a melhor amiga de Sookie, Tara, deixa um emprego para trabalhar para Sam Merlotte no seu bar e churrasqueira e o irmão traquinas de Sookie, Jason, vê-se em sarilhos quando um "fangbanger" de quem é íntimo tem um fim trágico.

Bill paga o favor de Sookie salvando-a da vingança dos Rattrays, curando a empregada de mesa ferida com o seu próprio sangue e deixando-a, temporariamente, com sentidos intensificados. Tendo sido convidado para a casa da Avó para um reunião "vamos conhecê-lo" com Jason e a família dela, Bill junta-se a Sookie para uma estadia noturna. Acabam na propriedade delapidada de antes da Guerra Civil de Bill, onde este combate os seus impulsos primários de vampiro em relação a uma aquiescente Sookie. Mais tarde, os desejos de Sookie levam a melhor e ela regressa a casa de Bill — onde é recebida por um grupo de amigos vampiros sanguinários.

Derrotados na sua tentativa de "enfeitiçar" Sookie, os vampiros Malcolm, Liam e Diane retiram-se precipitadamente quando Bill reivindica a empregada de mesa. No Merlotte's, Sam procura uma cura de curto prazo para a sua solidão a longo prazo e Tara procura uma folga da ira alimentada a álcool da mãe. Rejeitado por Dawn por falta de desempenho, Jason vira-se para Lafayette, o cozinheiro de refeições rápidas do Merlotte's, em busca de ajuda para o seu problema.

Outra morte em Bon Temps volta a pôr Jason sob a custódia dos agentes Andy e Bud. Tara consegue livrá-lo, mas nem ela nem Lafayette tem o antídoto para a sua atual maleita. Incentivada pela Avó a usar as suas capacidades telepáticas para descobrir o assassino e exonerar Jason, Sookie persuade Bill a levá-la a um bar de vampiros de Shreveport chamado Fangtasia, onde impressiona um sugador de sangue nórdico dominante chamado Eric com os seus poderes de presciência.

Repudiado por uma exasperada Sookie, Bill acaba por conquistar o público da igreja de Adele com as suas vívidas recordações da Guerra Civil, embora Andy e Bud continuem desconfiados. Sam tenta aproveitar ao máximo a sua oportunidade com Sookie, apesar de esta não estar claramente pronta para um compromisso. Ignorando a rejeição de Tara, Lafayette convence Jason a dar nova oportunidade ao sangue de vampiro, ou "suco V". Sozinho em casa, Bill recorda um doloroso incidente da guerra que mudou para sempre o seu destino.

Entorpecida pela tragédia, Sookie procura refúgio da cacofonia das vozes interiores dos seus amigos e vizinhos. Tendo disparatado com a irmã e atacado Andy, Jason debate-se com sintomas de desmame do seu vício de suco V. Tara resiste às propostas da sua mãe, Lettie Mae, que está a tentar livrar-se de um demónio e precisa da ajuda da filha. Sam e Tara criam uma ligação devido à sua busca mútua por "algo real".

A dolorosa revelação da infância de Sookie sobre o seu Tio Bartlett incita Bill a agir. Apesar do seu ceticismo, Tara aceita pagar um exorcismo para retirar um demónio de Lettie Mae. Em busca de suco V, Jason vai até ao Fangtasia, onde se liga a uma jovem mulher aventureira chamada Amy. Um trio de parolos decide fazer justiça à "vigilante" sobre um grupo de vampiros que entrou à força no Merlotte's em busca do seu teimoso companheiro, Bill.

Sookie tenta manter a compostura no seguimento de outra possível tragédia. Tara fica espantada com a reviravolta em Lettie Mae e pondera uma terapia similar para si depois de disparatar com Sookie e Sam. A nova querida de Jason, Amy, encanta a malta no Merlotte's, mas mostra a Jason um lado mais negro quando a fonte do seu suco V seca. Rene pede Arlene em casamento com Sookie a fazer de baby-sitter dos filhos dela. Mais tarde, a pedido de Bill, Sookie aceita usar os seus talentos para ajudar Eric, um poderoso xerife vampiro, a descobrir um ladrão no Fangtasia.

Bill quebra um tabu vampírico ao proteger Sookie — e tem de pagar um pesado preço por isso. Jason e Amy quebram o seu próprio tabu ao raptarem um vampiro chamado Eddie para recolherem o seu sangue. Com Lettie Mae aparentemente curada, Tara, cética, consulta Miss Jeanette sobre exorcizar o seu próprio demónio interior. Sookie regressa a casa para mais uma tragédia horrenda, o que leva Bill a recrutar um guarda-costas improvável — Sam — para a proteger enquanto ele está fora.

Apanhado numa posição comprometedora, Sam partilha um segredo com uma incrédula Sookie. Pensando que foi purgada dos seus demónios, Tara celebra com Lettie Mae — mas passa-se a sério quando descobre as verdadeiras intenções de Miss Jeanette. Sookie tem uma revelação perturbadora durante a festa de noivado de Arlene e Rene no Merlotte's. Num tribunal de vampiros para decidir a sua sorte, Bill enfrenta uma dura penalização pela sua ofensa, mas o magistrado opta por uma sentença mais criativa que envolve uma jovem humana chamada Jessica.

Bill satisfaz as condições da sentença do tribunal, apesar de ele e Eric acharem que Jessica não saiu bem como esperavam. Ao tentar resolver o mistério por detrás da sua visão mais recente, Sookie dirige-se a uma loja de empadas com Sam e, mais tarde, aperta com um polícia mulherengo para obter informações. Jason ajuda a limpar as confusões de Amy, preocupado com o futuro de ambos mas incapaz de se afastar. A ira de Tara sobre a recusa de Lettie Mae de lhe pagar a caução para sair da cadeia é temperada quando um abastado "assistente social" vem em seu socorro. Indignado com a hipocrisia de um Senador Estatal que deita abaixo vampiros, Lafayette decide fazer-lhe uma visita em primeira mão no seu percurso de campanha. Na ausência de Bill, uma vulnerável Sookie encontra conforto em Sam. Jason, destroçado, vê-se novamente em sarilhos com Bud e Andy.

Sookie encontra uma ligação à série de mortes em Bon Temps — e acaba por ficar na mira perversa do assassino. Tara decide aproveitar ao máximo a sua segunda oportunidade com Maryann; Jason descobre uma nova vocação quando um fanático antivampiros chamado Orry o visita na cadeia; Bill tenta o destino na sua mais recente tentativa para salvar Sookie; Sam fica perturbado por um encontro com um antigo conhecido; Lafayette vê-se no local errado no momento certo.

A shocking murder outside Merlotte's has Bon Temps reeling. Meanwhile, Sookie's relationship with Bill is tested when she learns about Jessica, and of his involvement in her uncle's death. Sam recalls a shape-shifting encounter he had with Maryann as a 17-year-old. Jason gets a sudden windfall that allows him to pay for a leadership retreat with the Fellowship of the Sun. Two adversaries find themselves sharing a mysterious dungeon and, possibly, the same fate.

Sookie is forced to babysits Jessica, as well as the romantic inconveniences the teen vampire's presence creates. At the Light of Day leadership conference, Jason makes an impression on its ambitious leaders, Steve and Sarah Newlin. While one of his fellow campers, Amanda Jane with her band, the God Rockets, livens the spirits at camp with their hit single, Jesus Asked Me Out Today. Maryann casts her spell on Merlotte's patrons.

Bill and Eric team up to save Sookie from a mysterious creature. Jason has second thoughts about the Light of Day retreat anti-vampire agenda, but Sarah and Steve counter his doubts with flattery and promises. Sam leaves town after alienating everyone. Jessica heads over to Merlotte's, where a smitten Hoyt falls for her. Tara is attracted to Eggs but is rudely interrupted by a fog.

Bill and Sookie travel to Dallas to carry out Eric's mission; Jason falls victim to a practical joke; Maryann throws a birthday party for Tara.

While in Dallas, Sookie connects with one of her own; Jason is rewarded for his hard work at the Light of Day boot camp; Eric shares a secret about his past with Bill. Lafayette is given his job back.

Sookie embarks on a dangerous mission to locate Godric. Bill is shocked when a vampire from his past resurfaces in Dallas and keeps him hostage. Jason makes some difficult decisions. Andy interrogates Lafayette about his disappearance, Terry intervenes.

Drunken Andy helps Sam escape from Maryann's clasp. Sookie uncovers the traitor. Sam confront Daphne to discover Maryann is a Maenad. Jason gets caught fleeing the L.O.D. church by Sarah. Eric overhears Barry's message to Bill and goes to Sookie's aid.

Sookie's captivity takes an unexpected turn; Sam makes a gruesome discovery at Merlotte's; Tara and Eggs eat a mysterious meal prepared by Maryann; Jason pays off his debt to Eric.

A wounded Eric plays Sookie for a sucker, to Bill’s dismay, and ends up getting inside her head. Later, Sookie and Jason bond over their recent adventures. Blaming Eggs for Tara’s bruises and bizarre behavior, Lafayette and Lettie Mae try to figure out a way to pry their kin from Maryann’s clutches. Hoyt defends his relationship with Jessica to Maxine, to no avail. Jailed by Bud along with a group of Bon Temps revelers, Sam looks for a way to escape and avoid capture by an increasingly obsessed Maryann. In Dallas, Eric and the vampires defend their recent actions to Nan Flanagan and are shocked when Godric decides to take the fall for their PR disaster.

Sookie, Bill and Jason return to a Bon Temps turned upside down by Maryann. Lured to Merlotte’s by Arlene, Sam and Andy find cold comfort in their refuge from a group of bloodthirsty revelers. Bill discovers that traditional vampire techniques don’t work on Maryann; Hoyt and Jessica try to keep a lid on Maxine’s madness; and Sookie tries to push through the darkness consuming Tara. With all hell breaking loose, Jason takes the bull by the horns to rescue Sam, at least for the moment.

With the crisis in Bon Temps careening out of control, Bill seeks out the advice of Sophie-Anne, the Vampire Queen of Louisiana, but must exercise patience before she gives him critical information. Meanwhile, Sookie and Lafayette find that protecting Tara from herself is more difficult than they anticipated; a desperate Sam turns to an unlikely source for assistance; and Jessica tests Hoyt’s allegiance to Maxine.

Bon Temps reaches a fever pitch as Maryann prepares for her ultimate bestial sacrifice, conscripting Sookie to be Maid of Honor at the bloody nuptials. Meanwhile, Sophie-Anne warns Eric to keep the lid on Bill's inquisitiveness; Jason leads Andy into the heroic abyss; and Hoyt struggles with Maxine's endless stream of insults. Deliberating on what may be his final move to save Sookie and the town, Sam places his trust, and his life, in a most unlikely ally

Sookie turns to Eric for help finding Bill; Andy urges Jason to stay the course; Sam reconnects with his past; Tara seeks refuge from her grief.

Russell Edgington, the Vampire King of Mississippi, concocts a plan to consolidate his power. Eric remembers his past; Sam tests the strength of his family bonds; Tara finds an ally in a shady vampire named Franklin Mott.

In search of Bill, Sookie heads to Mississippi in the company of Alcide, a werewolf bodyguard. Haunted by visions from his past, Bill makes a surprising pledge of allegiance.

Sookie joins Alcide at a raucous engagement party for his former fiancee. Bill "procures" dinner for Russell and Lorena. Sam brokers a deal with Tommy and his parents. Andy gets a promotion and draws Jason's attention. Arlene is irked by Jessica's arrival at Merlotte's. Eric is given a deadline to locate Bill. Franklin takes Tara on a road trip.

Alcide and Sookie turn to an alpha-wolf "packmaster" for advice on how to deal with Russell's minions. Tara considers a proposal from Franklin, who's completed his mission for Russell; Joe Lee breaks his promise to Sam and Tommy; Lafayette learns the meaning of patience from Jesus, his mother's orderly; Jason meets his match in a mysterious girl named Crystal. An heirloom reminds Eric of his past and his ongoing thirst for vengeance.

Spurned by Eric, Sookie fears the worst for Bill, whose fate now lies in Lorena's hands. Fueled by a night of bloody passion, Tara executes a desperate plan to stave off Franklin's advances. In Bon Temps, Tommy finds it difficult to leave the family nest; Jessica gets her fix from a Merlotte's customer; and Jason's romance with Crystal hits a snag, as does Lafayette's with Jesus. After revealing his master plan to Eric, Russell pays a visit to Louisiana in order to start executing it.

Sookie's attempt to rescue Bill has unforseen consequences. Meanwhile, Jason seeks the truth about Crystal. Sam must step in when Tommy gets involved in a dog fighting ring, all thanks to Melinda and Joe Lee's quest for money. Eric figures out how to get the information he wants from Sophie-Anne. Debbie plans to get even with Alcide while Russell ignores the Magister.

While Sookie must rethink her relationship with Bill, he reconciles with Jessica. As Russell decides what he's going to do next, Sophie-Anne relocates her residence. Jason offers a challenge to save Crystal while Ruby Jean pays Lafayette a surprise visit. A new waitress starts at Merlotte. Eric's allegiance to Russell is proven. Alcide's family emergency puts Sookie in a vulnerable position.

The Vampire Rights Amendment is close to being ratified so Nan confronts Eric at Fangtasia about the whereabouts of the Magister. Russell vows revenge against all his vampire and human adversaries. Bill discovers the truth about Sookie's true identity. Unexpected help arrives as Jason goes up against Felton and Calvin. Arlene is overcome by a sense of futility about her future while Tara meets up with a new ally and with someone who caused her pain in the past. Sookie meets a new family member. Hoyt addresses his real feelings head on.

Sookie is warned about the dangers she will have to deal with. Dark memories surface for Sam. Arlene must ask Holly for help while Jason faces unexpected dealings with Tara and Crystal. Jesus' interest in V's qualities is aroused. Arlene seeks out Holly for help. Russell vows to inflict punishment on his enemies. After precautions, Eric satisfies a wish.

Bill wants to earn back Sookie's trust but once again brings her close to danger. Eric tempts Russell with "ultimate vampire dream". Jason tries to comprehend what he's learned about Crystal. Sam alienates everyone but Tara. Jessica and Hoyt take their romance up a notch. Lafayette struggles with new demons.

Eric plots his revenge against Russell; Sookie considers a new life without Bill; Tara discovers some surprising news about Sam; Jason finds a new calling; Lafayette turns to Jesus for help; Hoyt hopes for a future with Jessica.

Sookie journeys away from Bon Temps; Eric and Bill try to win back the human public; Jason learns that no good deed goes unpunished; Tara finds refuge in close quarters; Sam bonds with his own; Hoyt and Jessica debate the dinner menu; Jesus urges Lafayette to join a coven; and Terry tries to alleviate Arlene’s fears about the baby.

Sookie adjusts to Bon Temps' new realities; Bill reveals pieces of his past; Eric crashes a witches' meeting; Jason gets his wounds licked; Andy struggles with his addiction; Sam learns of Luna's special talents; Jessica satisfies her blood cravings; and Arlene witnesses strange behavior from her family.

Sookie makes a deal with Eric and reconnects with Alcide; Bill punishes an errant vampire and counsels a guilt-ridden Jessica; Jason is cast as a reluctant savior; Tommy eyes a scam and alienates Sam; Marnie flexes her newfound powers; Pam delivers an ultimatum to Lafayette, Tara and Jesus; Eric spoils Sookie's faerie reunion.

Alcide helps Sookie hunt for Eric; Marnie searches for guidance to break a spell; Bill discovers a common bond with the Bellefleurs; Jason begs for liberation from Hotshot; Sam penetrates Luna's inner circle; Arlene sees the writing on the wall; Tommy returns to his roots.

Sookie nurtures Eric; Bill gets involved personally in the necromancy crisis; Pam takes the veil; Sam becomes Tommy's accomplice; Arlene and Terry look to religion to solve their problem; Jesus and Lafayette head to Mexico to harness a shaman's power; Jason convalesces.

Sookie searches for Jason under a full moon; Marnie connects with spirits of the past; Arlene and Terry cope with a suspicious inferno; Debbie urges Alcide to join a new werewolf community; Tommy trades places with Sam; Lafayette feels the spirit in Mexico; Eric surrenders to his King's will.

With Marnie empowered by spirits of the dead, Bill issues an unpopular order to save vampires from the light. Eric embraces his amnesia; Luna discovers Sam’s not the man she thought he was; Lafayette expands his consciousness; Pam gets a body peel; Andy’s date with Holly doesn’t go as planned; Jessica has doubts about her future with Hoyt; Alcide and Debbie join a new pack.

Bill and Marnie get ready for an open confrontation. The King secures the loyalty of Sookie and Eric. Jason is conflicted emotionally. A spirit manipulates Lafayette for its own purposes. Sam must deal with Marcus who just happens to be Luna's ex.

Sookie tries to figure out how to fit both Bill and Eric into her life. Lafayette needs Jesus' help to rid him of the spirit that has taken over. Alcide is called upon by Marcus to help render assistance. Opposing ideas bring Bill into direct conflict with Nan. Marnie secretly plans out the strategy for her next step against the vampires in spite of Tara and Holly's apprehension about the outcome.

Bill needs Sookie to use her powers which results in breaking a spell. Jessica is implored to glamour Jason. Terry tries to help Andy with an intervention. Alcide reassesses his loyalties. Bill organizes the vampires to attack Marnie's Moon Goddess Emporium while Jesus, Lafayette, Sookie and Jason attempt to free Tara and Holly.

It's up to Sookie and her powers to keep Bill, Eric and Pam from harm. While Jesus casts a spell, Lafayette is totally absorbed by the past. Sams gets even with Marcus and Alcide deals with Debbie head on. Andy's foray into the forest is filled with deep, overwhelming emotion.

The souls of the dead rise up in Bon Temps. Sookie makes some important associations. Jesus and Lafayette's connection is imperiled. Sam and Luna imagine a happy and perfect future. Sookie and Tara are confronted by Debbie.

Sookie and Lafayette clean up the mess. Bill and Eric have a visit from the Vampire authority. Sam and Alcide come to terms with an angry pack.

Tara resurfaces in Bom Temps. Pam recalls her human life when she met Eric.

Bill and Eric barter for their lives with Roman, the head of the Authority; Jason reunites with his old high school teacher; Sookie searches for Tara.

Eric and Bill fear for their lives; Lafayette puts Sookie’s life in danger; Roman and Salome root out a Council traitor.

Bill and Eric turn to Sookie for help with Russell’s whereabouts; Jason has a disturbing dream.

Bill and Eric must now face Russell again after Roman is killed by him; Sookie and Jason go to a faery club where their family's dark history and greatest secrets are revealed to them. Meanwhile, Sam volunteers to assist Andy with a case.

Salome reveals her true allegiances; Sookie embraces her human side; Sam sniffs out some perps; Alcide braces for a fight.

The Authority revels in a new direction; Sookie and Jason visit the site of their parents’ deaths; Luna gets stuck on Sam.

Vampires celebrate the start of the holy war; anti-supernatural zealots put Sookie in danger.

Bill puts a spin on the rising vampire violence; Jason uncovers a mysterious scroll.

Bill slips into religious fervor; Sookie seeks insight from the faerie Elder.

Eric tries to save Bill from losing his humanity.

A group flees the Authority compound in the wake of Bill's reincarnation; Sam, Luna and Emma evade guards; Alcide learns about the packmaster job; Andy parents newborn human-faerie hybrids; Governor Truman Burrell vows open season on vampires.

Jason and Sookie meet a long-lost relative; Tara is victimized by a new government weapon; Eric attempts to thwart the governor's anti-vampire initiatives; Sookie is drawn to a stranger; Alcide and Martha confront Sam about Emma's future.

Eric is irate about Burrell's aggression towards vampires; Bill enlists an innovator to synthesize a new type of blood; Sookie begins to learn why Warlow is after her; Sam receives unexpected help from Nicole; Steve Newlin struggles with his past.

Sookie confronts her growing attraction to the mysterious Ben. Eric counters Burrell’s brutal anti-vampire initiatives by hitting his nemesis where it hurts the most. Growing up all too quickly, Andy’s faerie daughters end up keeping dangerous company. Sam and Nicole make a connection. Bill tasks Takahashi to synthesize a new kind of blood.

Wanting to finally learn the truth about her past Sookie recruits Lafayette to summon her parents while Warlow relives the events that led him back to Lilith after thousands of years, Eric and Tara attempt to rescue Pam.

Sookie escapes to a Fae land where Bill cannot influence her. Bill decides to seek Lillith's advice. Eric, Pam, Nora, Jason and Jessica are in danger.

Eric pledges loyalty to Bill as a last resort to save Nora. A tragedy close to home forces Sam to ignore the warnings of Alcide and return to Bon Temps. Jessica shows her gratitude to James, a prisoner.

Sookie faces a major dilemma in deciding whether to broker a deal between Warlow and Bill. Over in vamp camp, Jason gets to know Violet, while Sarah goes to extremes to keep Tru Blood flowing. Alcide makes a decision that will impact the futures of Nicole and Sam.

A desperate Bill tries to ferry Warlow away from the faerie plain, but Sookie is having none of it. Meanwhile, Eric arrives at vamp camp, looking to inflict serious human damage. In Bon Temps, friends and family take emotional turns remembering a fallen neighbor. Bill feels the pull of Lilith’s sirens.

Jason feels a vampire attraction firsthand; and Bill finds that salvation isn't free. Meanwhile, Sookie considers her future with Warlow as a new crisis poses a threat to humans and vampires alike.

A band of rogue H-vamps crashes the vampire-human mixer at Bellefleur’s, with shocking results. As Sookie seeks refuge from accusations that she’s somehow to blame for the chaos in Bon Temps, the “one vampire for every human” plan moves forward. In the face of a vigilante insurrection led by redneck Vince, Bill receives aid from an unexpected source.

A trio of hostages taken in the Bellefleur’s attack looks to a familiar face as a possible liberator from the H-vamps. Sookie and Jason visit the neighboring town of Saint Alice, where a young woman’s diary offers clues to the potential fate of Bon Temps. Spurned by Lafayette, a desperate Lettie Mae turns to Willa to channel her family past. Vince whips his fellow vigilantes into a dangerous frenzy. Pam’s search for her maker leads her to a very familiar place.

Sookie hatches a dangerous plan to take down the H-Vamps, even as Vince and his armed vigilantes pose an equally serious threat. Lafayette gets high with James; Jason eyes a family future with Violet; Willa is forced to find a new place to stay; Sarah Newlin sheds her past. Pam offers Eric a compelling reason to return to Louisiana – and be the vampire he used to be.

In the aftermath of yet another bloodbath, Sam, Sookie and Jason find themselves the bearers of bad news in Bon Temps and beyond. Pam recalls the events that led her and Eric to Shreveport and Fangtasia. Bill and Jessica get nourishment from unexpected sources. Following a new lead, Sookie enlists a band of vampires and humans to track down the H-Vamps.

Exhausted from her recent travails, Sookie finds herself the unwilling host of a festive mainstreaming party in Bon Temps. In search of an elusive adversary, Eric and Pam head to Dallas and attend a gala fundraiser. Andy makes a life-changing decision; Jessica and James reach a crossroads; Bill loses himself in remembrance of human days.

Eric and Pam find a new ally in their search for a common enemy; Sookie makes a startling discovery that forces her to rethink her recent involvement with Bill; Lafayette shares a vision with Lettie Mae; Jason realizes how he really feels about Violet; Sam isn't sure what to do about Nicole.

Sookie looks for a miracle; Eric and Pam zero in on Sarah Newlin; Adilyn and Wade seek protection from Violet.

Eric mulls his options; Sookie puts her life on the line for Bill; Lettie Mae finds closure; Violet has revenge on her mind.

Bill alienates Sookie; Hoyt remembers the past; Eric faces a dilemma.

Sookie weighs a future with and without Bill. Eric and Pam struggle with their uncomfortable partnership with Mr. Gus. Sam makes a choice, while Andy comes upon an unexpected inheritance. Series Finale.