Thirty years ago, aliens arrive on Earth. Not to conquer or give aid, but to find refuge from their dying planet. Separated from humans in a South African area called District 9, the aliens are managed by Multi-National United, which is unconcerned with the aliens' welfare but will do anything to master their advanced technology. When a company field agent contracts a mysterious virus that begins to alter his DNA, there is only one place he can hide: District 9.

A young woman named Dorothy Gale dreams of becoming a singer but is unable to pursue her dreams. After being swept up by a tornado with her pet prawn Toto, Dorothy embarks on a journey to meet the Wizard of Oz, the person who both Dorothy and the citizens of Oz believe can help make her dream come true.