The students of Suzuran High compete for the King of School title. An ex-graduate yakuza is sent to kill the son of a criminal group, but he can't make himself do it as he reminds him of his youth.

Genji and his victorious G.P.S. alliance find themselves facing down a new challenge by the students of Hosen Academy, feared by everyone as 'The Army of Killers.' The two schools, in fact, have a history of bad blood between them. And the simmering embers of hatred are about to flare up again, burning away any last remnants of the truce they had so rigorously observed until now.

Black Jack is a master surgeon who possesses impeccable skills, enabling him to perform operations that are impossible for even the finest surgeons. He now is faced with his most difficult task to date and must challenge the limits of medical science...before it's too late!

The Persona Century Corporation has purchased nearly every parcel of land on earth. Dissension is not tolerated within the corporation's borders and those who oppose Persona are dealt with swiftly. Of those few places not yet under Persona's control is the free town of Kabuki-cho, also known as "The Dark Side of Tokyo". Within the town, under the leadership of a woman named Mai, is a small resistance group called Messiah. Into this world steps a man who takes the sobriquet of Kabuki-cho: Darkside. Sealed up in another dimension eighteen years ago by Persona Century, Darkside now returns to aid Messiah using his unique mystic power of renewal.

Black Jack is approached by a defecting soldier and his wife with a plea to help their son, who is afflicted with a rare disease. Although it might already be too late for the boy, Black Jack is able to save the child. But at what cost?