After narrowly escaping a bizarre accident, a troubled teenager is plagued by visions of a large bunny rabbit that manipulates him to commit a series of crimes.

Best friends Alice and Darlene take a trip to Thailand after graduating high school. In Thailand, they meet a captivating Australian man, who calls himself Nick Parks. Darlene is particularly smitten with Nick and convinces Alice to take Nick up on his offer to treat the two of them to what amounts to a day trip to Hong Kong. In the airport, the girls are seized by the police and shocked to discover that one of their bags contains heroin.

Upon receiving reports of missing persons at Fort Spencer, a remote Army outpost on the Western frontier, Capt. John Boyd investigates. After arriving at his new post, Boyd and his regiment aid a wounded frontiersman who recounts a horrifying tale of a wagon train murdered by its supposed guide -- a vicious U.S. Army colonel gone rogue. Fearing the worst, the regiment heads out into the wilderness to verify the gruesome claims.

Seven years after the events of the first film, Samantha Darko finds herself stranded in a small desert town after her car breaks down where she is plagued by bizarre visions telling of the universe's end. As a result, she must face her own demons, and in doing so, save the world and herself.